![]() The clinical significance of this finding is unknown.ĭevelopment of resistance to nitrofurantoin has not been a significant problem since its introduction in 1953. The broad-based nature of this mode of action may explain the lack of acquired bacterial resistance to nitrofurantoin, as the necessary multiple and simultaneous mutations of the target macromolecules would likely be lethal to the bacteria.Īntagonism has been demonstrated in vitro between nitrofurantoin and quinolone antimicrobials. Nitrofurantoin is bactericidal in urine at therapeutic doses. As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA synthesis, and cell wall synthesis are inhibited. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other acromolecules. ![]() The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials.
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