![]() ![]() Editor's evaluationĪir pollution has become the prominent environmental risk factor that affects public health ( Caplin et al., 2019). In summary, our study defines a novel atmospheric environmental mechanism that mediates PM-aggravated microglia pathogenic activities, and establishes a systematic approach for the investigation of the effects of environmental exposure in neurologic disorders. Indeed, pharmacological disturbance combined with RNA-seq and ChIP-seq suggests that TLR-4/NF-kB signaling mediated a core network of genes that control PM-triggered microglia pathogenicity. Using multiple in vivo and in vitro strategies, in the present study we demonstrate that PM exposure aggravates neuroinflammation, myelin injury, and dysfunction of movement coordination ability via boosting microglial pro-inflammatory activities, in both the pathological demyelination and physiological myelinogenesis animal models. Increasing epidemiological studies demonstrated that PM plays a significant role in CNS demyelinating disorders however, there is no direct testimony of this, and yet the molecular mechanism by which the occurrence remains unclear. Atmospheric Particulate Matter (PM) is one of the leading environmental risk factors for the global burden of disease.
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